Principal Investigators
Elisabeth Battinelli, M.D., Ph.D.

Elisabeth Battinelli, M.D., Ph.D.

Principal Investigator

Elisabeth Battinelli is an Assistant Professor of Medicine at Harvard Medical School and an Associate Physician at Brigham and Woman’s Hospital. She received her M.D. Ph.D. from Boston University School of Medicine, where her thesis with supervisor Joseph Loscalzo focused on the role of nitric oxide in regulating platelet production. Following her graduation, Dr. Battinelli undertook a Hematology/Oncology Fellowship at Beth Israel Deaconess Hospital with Joseph Italiano Jr., studying the regulation of angiogenesis by platelets. Now with the BWH Platelet Group, Dr Battinelli’s research focuses on how platelets differentially release angiogenesis regulatory proteins in the setting of malignancy.

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Joseph Italiano Jr., Ph.D.

Joseph Italiano Jr., Ph.D.

Principal Investigator

Joseph Italiano is an Associate Professor of Medicine and holds academic appointments at Brigham and Women’s Hospital, Boston Children’s Hospital and Harvard Medical School. He was awarded his Ph.D. in Cell Biology from Florida State University, under the supervision of Thomas Roberts. His thesis focused on how filament assembly and bundling contribute towards cell crawling in amoeboid sperm of Ascaris. Since then, Dr. Italiano transitioned into hematology-based research with John Hartwig at Brigham and Women’s Hospital, where he first began studying the cytoskeletal mechanisms of blood platelet formation, which remains a focus of his work as a Principal Investigator at the BWH Platelet Group.

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Kellie Machlus, Ph.D.

Kellie Machlus, Ph.D.

Principal Investigator

Kellie received her B.S. in Biochemistry from the University of Delaware. She then obtained her Ph.D. in Pathology at the University of North Carolina at Chapel Hill under the mentorship of Alisa Wolberg studying the association between hypercoagulability and thrombosis. Dr. Machlus then completed her postdoctoral fellowship at Brigham and Women’s Hospital and Harvard Medical School with Joseph Italiano where she examined mechanisms that modulate and trigger proplatelet formation from megakaryocytes. She now runs an independent lab at Harvard Medical School where she focuses on mediators of megakaryocyte differentiation, maturation, and platelet production, with a strong focus on how these things are modulated during inflammation.

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Postdoctoral Fellows
Nathan Asquith, Ph.D.

Nathan Asquith, Ph.D.

Postdoctoral Research Fellow

Nathan was awarded his B.S. molecular and cell degree from the University of Huddersfield, U.K. in 2013, followed by his Ph.D. from the University of Leeds, U.K. in 2019. Nathan’s Ph.D., in the laboratory of Robert Ariёns used recombinant protein expression methods and advanced biophysical and imaging to study the role of extended knob-hole interactions in fibrin polymerization and how key residues affected fibrin clot formation in relation to thrombosis. Nathan’s current work in the BWH Platelet group focuses on the roles of vascular thiol isomerases in thrombosis.

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Shauna French, Ph.D.

Shauna French, Ph.D.

Postdoctoral Research Fellow

Shauna completed her Ph.D. at Monash University, at the Australian Centre for Blood Diseases in the laboratory of Justin Hamilton. Here, she examined the role of platelet thrombin receptors during thrombosis, and developed novel anti-platelet therapeutics against these receptors. Shauna is now interested in uncovering molecular mechanisms regulating platelet production and identifying new drug targets for thrombocytopenia recovery.

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Harvey Roweth, Ph.D.

Harvey Roweth, Ph.D.

Postdoctoral Research Fellow

Harvey was presented a B.S. degree in Biomedicine at the University of Reading, U.K, before undergoing and completing his Ph.D. at the University of Cambridge, U.K. His thesis focused on the off-target effects of anti-depressants on platelets, within the laboratory of Gavin Jarvis. Harvey’s current projects within the BWH Platelet Group focus on the interactions between platelets, megakaryocytes and cancer.

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Martina Slingsby, Ph.D.

Martina Slingsby, Ph.D.

Postdoctoral Research Fellow

Martina received her B.S. in Pharmacology, at University College London, and her Ph.D. in Pharmacology, at Imperial College, London. Her Ph.D. was conducted in the Laboratory of Jane Mitchell, studying the cardiovascular side effects of non steroidal anti-inflammatory drugs. Before joining the BWH Platelet Group, she also underwent two postdoctoral fellowships at the William Harvey Research Institute under Timothy Warner, and at the University of Copenhagen with Ylva Hellsten, where she secured her own research funding studying the effects of physical activity on platelet function and effectiveness of anti-platelet drugs. Her current areas of interest include drug-induced thrombocytopenia.

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Adrian Wilkie, Ph.D.

Adrian Wilkie, Ph.D.

Postdoctoral Research Fellow

Adrian earned his B.A. in Molecular and Cell Biology from the University of California, Berkeley and his Ph.D. in Virology from Harvard University. During his graduate training in Donald Coen’s lab at Harvard Medical School, Adrian used biochemical, cell biological, and advanced imaging approaches to study the trafficking of human herpesvirus capsids in the host cell nucleus. Adrian maintains an interest in cellular dynamics as a postdoctoral fellow in the Italiano lab where he studies the cytoskeletal mechanisms that drive megakaryocytes to produce platelets.

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Laboratory Manager
Anjana Ray, Ph.D.

Anjana Ray, Ph.D.

Research Laboratory Manager

Anjana was awarded her Ph.D. in Plant Pathology from G.B. Pant University of Agriculture and Technology, India, with supervision from Pradeep Kumar Gupta. Anjana’s roles within the BWH Platelet Group predominantly involve managing the culture and development of fetal-derived murine megakaryocytes, supervising general laboratory maintenance, and participating in various platelet- and megakaryocyte-based projects.

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Research Assistants
Annie Tsai

Annie Tsai

Technical Research Assistant I

Annie received her B.S. from Taipei Medical University. Her current interests include determining mechanisms of drug-induced thrombocytopenia and visualizing platelet production by Megakaryocytes under flow conditions.

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Michael Malloy

Michael Malloy

Technical Research Assistant II

Michael received his B.A. in Molecular Biology from Colgate University, New York. He worked in the laboratory of Engda Hagos on the role of Epigenetics in colorectal cancer. Michael’s current interests include platelet modifications during malignancy and the atypical roles of apoptosis in platelet function.

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Anthony Sciaudone

Anthony Sciaudone

Technical Research Assistant II

Anthony received his B.A. in Biology from Boston University, Massachusetts. His research interests include studying Alzheimer’s disease and hematology, and he currently investigates the roles(s) of the megakaryocyte cytoskeleton in platelet production.

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Students
Lillian Horin

Lillian Horin

Ph.D. Candidate

Lillian received her B.A. in Biology at Pitzer College, California, before starting her Ph.D. at Harvard, with joint supervision from Joseph Italiano Jr. and Tim Mitchison. Her thesis will involve studying maintenance and formation of the microtubule coil in platelets.

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Benjamin Posorske

Benjamin Posorske

Undergraduate Student

Benjamin is an undergraduate student at Boston College studying the role of the centrosome and cell cycle in platelet formation as well as engaging in various platelet- and megakaryocyte-based projects with joint supervision from Dr. Joseph Italiano Jr. and Dr. Kellie Machlus.
Support Staff
Ella Green

Ella Green

Administrative Assistant II

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Alumni

Brett Losen

Brett Losen

Senior Grant Administrator (2018-2019)

Somayje Parvin.<br />

Somayje Parvin.<br />

Medical Student (2018).

Visiting Medical Student from the University of Würzburg, Germany.
Lelia Noetzli

Lelia Noetzli

Research Fellow (2017-2019)

Now a Scientist at Alnylam Pharmaceuticals.

 

Prakrith Vijey

Prakrith Vijey

Technician (2016-2019)

Now a Data Scientist at Pfizer.
Genevieve Couldwell

Genevieve Couldwell

Technician (2016-2019)

Now a Graduate Student in the Molecular Biology Program at the University of Utah.
Julia Ceglowski

Julia Ceglowski

Technician (2016-2018)

Now a Ph.D. Candidate at University of Colorado, Denver.
Brooke Terkovich

Brooke Terkovich

Technician (2018-2019)

Now a Medical Student on the Anschutz Medical Campus at the University of Colorado.
Kelly Johnson, Ph.D.

Kelly Johnson, Ph.D.

Research Fellow (2014-2017).

Now a Medical Science Liaison at Ipsen.